{"id":14220,"date":"2024-04-15T09:19:46","date_gmt":"2024-04-15T07:19:46","guid":{"rendered":"https:\/\/downgalicia.org\/a-sindrome-de-down-e-hereditaria\/"},"modified":"2026-07-14T14:16:38","modified_gmt":"2026-07-14T12:16:38","slug":"a-sindrome-de-down-e-hereditaria","status":"publish","type":"post","link":"https:\/\/downgalicia.org\/gl-lf\/a-sindrome-de-down-e-hereditaria\/","title":{"rendered":"A s\u00edndrome de Down \u00e9 hereditaria?"},"content":{"rendered":"

 <\/p>\n

A d\u00eda de hoxe, a\u00ednda existen na poboaci\u00f3n moitas d\u00fabidas e preguntas ao redor da s\u00edndrome de Down. Para dar resposta a todas elas, e as\u00ed evitar a aparici\u00f3n de mitos sobre el s\u00edndrome de Down<\/a>, preparamos este post no que explicamos as causas que o orixinan e lanzamos un pouco de luz sobre unha das cuesti\u00f3ns m\u00e1is habituais: \u00e9 a s\u00edndrome de Down hereditaria?<\/p>\n

S\u00edndrome de Down: causa xen\u00e9tica<\/h2>\n

Antes de aclarar se a s\u00edndrome de Down \u00e9 hereditaria ou non, \u00e9 importante que queden claros alg\u00fans conceptos relacionados coa xen\u00e9tica<\/strong>. Desta forma, resultar\u00e1 moito m\u00e1is sinxelo chegar a comprender a resposta.<\/p>\n

O material xen\u00e9tico dun ser humano, tam\u00e9n co\u00f1ecido como ADN, est\u00e1 composto por 23 pares de cromosomas<\/strong>. Sen embargo, as c\u00e9lulas sexuais soamente te\u00f1en unha copia de cada cromosoma. \u00c9 dicir, os \u00f3vulos e os espermatozoides soamente te\u00f1en 23 cromosomas<\/strong>. Da uni\u00f3n de ambos xurde un novo organismo cos 23 pares de cromosomas necesarios, 23 do \u00f3vulo e outros 23 do espermatozoide. Esta primeira c\u00e9lula, ou cigoto, ir\u00e1 divid\u00edndose pouco a pouco<\/strong> para dar lugar ao feto. Durante esta divisi\u00f3n tam\u00e9n se dividen os 46 cromosomas ata que cada c\u00e9lula te\u00f1a os seus 23 pares de cromosomas.<\/p>\n

Con todo, hai casos nos que, durante o proceso de concepci\u00f3n, o \u00f3vulo ou o espermatozoide aporta 24<\/strong> cromosomas e non 23. \u00c9, por exemplo, o que ocorre coa s\u00edndrome de Down<\/a>. Esta alteraci\u00f3n no n\u00famero de cromosomas ten lugar cando hai unha presencia extra do cromosoma 21, de a\u00ed que tam\u00e9n se co\u00f1eza como trisom\u00eda 21.<\/p>\n

 <\/p>\n

Causas xen\u00e9ticas da s\u00edndrome de Down: factores de risco<\/h2>\n

\u00c9 certo que a\u00ednda non se sabe a causa exacta que produce a alteraci\u00f3n de cromosomas que desencadea a aparici\u00f3n da s\u00edndrome de Down, pero si existen alg\u00fans factores que parece que aumentan as probabilidades de que un fillo ou filla naza coa alteraci\u00f3n xen\u00e9tica. Estes son:<\/p>\n

Idade avanzada da nai<\/h3>\n

As mulleres nacen con todos os seus \u00f3vulos nos ovarios, a diferencia dos homes que van producindo regularmente os seus espermatozoides. Por iso, a medida que unha muller envellece, os seus \u00f3vulos tam\u00e9n o fan con ela<\/strong>. Canto m\u00e1is envellecen os \u00f3vulos, maiores son as probabilidades de ter un fillo ou filla coa s\u00edndrome de Down. De forma xeral, establ\u00e9cese como punto de corte os 35 anos. A partir desa idade, o risco \u00e9 maior.<\/p>\n

Que un dos proxenitores sexa portador de translocaci\u00f3n xen\u00e9tica pola s\u00edndrome de Down<\/h3>\n

Esta translocaci\u00f3n pode ser transmitida tanto por homes como por mulleres<\/strong>.<\/p>\n

Ter outro fillo ou filla coa s\u00edndrome de Down<\/h3>\n

As parellas que xa tivesen un fillo ou filla coa s\u00edndrome de Down te\u00f1en m\u00e1is probabilidades de volver a ter outro coa mesma alteraci\u00f3n. Est\u00e1 demostrado que o risco increm\u00e9ntase nun 1% antes dos 35 anos<\/strong>. Se a nai xa superou esta idade, estanse sumando dous riscos e, polo tanto, as posibilidades dupl\u00edcanse.<\/p>\n

 <\/p>\n

Ent\u00f3n, \u00e9 hereditaria a s\u00edndrome de Down?<\/h2>\n

A resposta a se a s\u00edndrome de Down se herda \u00e9 que non en gran parte dos casos.<\/strong> O habitual \u00e9 que se produza de forma fortu\u00edta e casual. Sen embargo, existe unha porcentaxe moi pequeno, en torno ao 1%, no que si hai unha herdanza dos pais. Estamos falando dos casos de translocaci\u00f3n<\/strong>, nos que os proxenitores non te\u00f1en a s\u00edndrome pero un deles, m\u00e1is frecuentemente a nai, transm\u00edteo \u00e1 s\u00faa descendencia.<\/p>\n

Os casos de translocaci\u00f3n, nos que a s\u00edndrome de Down \u00e9 hereditario, danse en aproximadamente un 3,5% das persoas diagnosticadas<\/strong>. En lugar de ter unha trisom\u00eda simple te\u00f1en 2 cromosomas do par 21 e un terceiro cromosoma 21 que est\u00e1 unido a outro dun par distinto ao 21 que, polo xeral, soe ser o 14.<\/p>\n

 <\/p>\n

Como se produce a translocaci\u00f3n?<\/h3>\n

Un de los proxenitores pos\u00fae, en lugar da habitual parella de cromosomas 21, un cromosoma 21 normal e outro que est\u00e1 unido a un terceiro cromosoma<\/strong>, como o 14. Neste caso, o proxenitor ten un cromosoma 21, un 14 e outro cromosoma 14-21. En lugar de ter os 46 cromosomas que compo\u00f1en o material xen\u00e9tico dunha persoa, ten 45. Con todo, non lle falta material xen\u00e9tico.<\/p>\n

Ao formarse os \u00f3vulos ou espermatozoides, algunhas c\u00e9lulas sexuais orixinaranse de forma correcta cos seus correspondentes 23 cromosomas; outras ter\u00e1n s\u00f3 22 cromosomas, sendo un deles o resultado da uni\u00f3n 14-21; ou, por \u00faltimo, presentar\u00e1n un cromosoma 21 m\u00e1is un cromosoma 14-21. Se a c\u00e9lula fecundada \u00e9 a que ten 2 cromosomas 21,\u00a0 o resultado ser\u00e1 un cigoto con 3 copias do cromosoma 21, unha delas en translocaci\u00f3n,<\/strong> unida ao cromosoma 14.<\/p>\n

En resumo, cando se herdan translocaci\u00f3ns, o pai ou a nai te\u00f1en parte do material xen\u00e9tico do cromosoma 21 reordenado en outro cromosoma, pero non material adicional. Isto implica que non presentan ning\u00fan signo de s\u00edndrome de Down, pero si poden transmitilo aos seus fillos ou fillas<\/strong> e facer que a s\u00edndrome de Down sexa hereditario.<\/p>\n","protected":false},"excerpt":{"rendered":"

  A d\u00eda de hoxe, a\u00ednda existen na poboaci\u00f3n moitas d\u00fabidas e preguntas ao redor da s\u00edndrome de Down. Para dar resposta a todas elas, e as\u00ed evitar a aparici\u00f3n de mitos sobre el s\u00edndrome de Down, preparamos este post…<\/p>\n","protected":false},"author":1,"featured_media":14221,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"give_campaign_id":0,"footnotes":""},"categories":[607],"tags":[],"class_list":["post-14220","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divulgacion-educativa-gl-lf"],"acf":[],"yoast_head":"\nA s\u00edndrome de Down \u00e9 hereditaria? • Federaci\u00f3n Down Galicia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/downgalicia.org\/gl-lf\/a-sindrome-de-down-e-hereditaria\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A s\u00edndrome de Down \u00e9 hereditaria? • Federaci\u00f3n Down Galicia\" \/>\n<meta property=\"og:description\" content=\"  A d\u00eda de hoxe, a\u00ednda existen na poboaci\u00f3n moitas d\u00fabidas e preguntas ao redor da s\u00edndrome de Down. 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